Estrogen

“This manuscript presents a protocol for hormone replacement therapy with natural estrodial, progesterone, testosterone, DHEA and melatonin. Using the natural sex steroids which occur naturally in humans represents replacement to ensure attainment of pre-menopausal levels and adequacy of therapy. This is inexpensive therapy that gives relief of symptoms, is well tolerated, provides minimal side effects, protects the endometrium, and results in excellent compliance. This replacement of natural hormones is based on sound physiologic principles that have been demonstrated to be the preferred method of hormone replacement.” Infertility and Reproductive Medicine Clinics of North America; 1995 October; Vol. 6(4): 653-675.

“Fear of breast cancer is the strongest factor limiting postmenopausal hormone use. The most powerful study to date definitively demonstrated that estrogen does not cause an increased risk for cancer. The increased risk was associated only with taking the progestin (Provera®) and not estrogen. JAMA 2004; 291(24): 2947-2958.

“Loss of hormones at menopause results in significant genital atrophy, vaginal dryness, introital stenosis, and painful intercourse.” Family Practice News 2005 March; 58-59.

“Estrogen deficiency greatly increases mortality from cardiovascular disease and osteoporosis. Over 90% of women will die from cardiovascular disease which estrogen can prevent.” Over 40 years of study have well documented the cardiovascular protective effects of estrogen.” Obstet Gynecol 1996 Jan; 87(1): 6-12.

“The potential lethal consequences of osteoporosis are overwhelming. Estrogen is protective but only when certain serum levels are maintained.” Female Patient Oct. 2004; Vol. 29: 40-46.

“Multiple medical studies have demonstrated estrogen’s protective effects against Alzheimer’s memory loss and loss of cognition.
Estrogen decreases colorectal cancer.
Estrogen decreases cataracts and macular degeneration.
Estrogen prevents tooth loss and gingivitis.
Estrogen prevents urogenital atrophy, painful intercourse and stress incontinence.”

Biomedica Jan. 2000; Vol. 3(1): 6-9.

“We must not forget the dangers of menopause and the deleterious consequences of estrogen deficiency. Estrogen protects bone, heart, brain, blood vessels, urogenital tissue, teeth and eyes. Observational data from around the world show estrogen has beneficial effects on mortality from all causes.” Consultant 2001 July; Vol. 71: 1085-1086.

“The largest study to date, the Nurses’ Health Study, demonstrated a 100% decrease in heart disease and cancer for estrogen users. It is never too late to initiate estrogen therapy to arrest the progression of osteoporosis and hip fractures.” Female Patient 2004 Oct; Vol. 29: 35-41.

“In the final analysis of the estrogen only arm of the WHI; there was no increased risk of breast cancer or heart disease. There was a 35% decrease in hip fractures, 35% decrease in diabetes and a 60% decrease in urinary sepsis. This leads to a significant decrease in all causes of mortality. J Gen Internal Medicine 2004; 19(7): 791-804.

“New findings in 4 recent studies counter the results of WHI and HERS. Estrogen replacement results in a dramatic decrease in cardiovascular disease. There were no coronary artery disease deaths reported in 6,000 women taking estrogen. The results of the WHI do not apply to younger women.” Family Practice News 2003 June; Vol. 33(11): 1-2.

“Estrogen reduces the incidence of Alzheimer’s disease by 50%. JAMA 2002; 288: 2123-2129.

“Estradiol and progesterone demonstrated no increased risk of breast cancer. Synthetic estrogen (Premarin®) and synthetic progestin’s (medroxyprogesterone and noresterone) all dramatically increased the risk of breast cancer. This was a ten year study of over 100,000 women, the largest and longest study to date comparing natural hormones to synthetic hormones.” Breast Cancer Res Treat 2007; 101: 125-134.

“The WHI trial had major design flaws that led to adverse conclusions about the positive effects of hormone therapy. The study included mostly older women that already had cardiovascular disease. The study utilized only medroxyprogesterone (Provera®) which we know negates any beneficial effect of estrogen, rather than the bio identical hormone, progesterone. Multiple other studies with estrogen started early in menopause demonstrate beneficial effects.” Fertility Sterility 2005 Dec. 84(6): 1589-601.

“Because of design flaws, the WHI trial should be discredited as it used only 2 synthetic hormones that were already known to be harmful. The positive effects of many different hormone methods studied over the last 50 years should not be discounted due to one poorly designed and flawed study (WH1) trial.” Female Patient 2004 Oct; Vol. 29: 40-46.

“North American Menopausal Society (NAMS) position statement. The WHI results do not apply to the majority of women. The WHI trial does not negate 40 years of study demonstrating HRT benefit. Five recent studies demonstrate overwhelming evidence that HRT prevents atherosclerosis.” Family Practice News 2003 Oct; 1-2.

“Estrogen lowers cortisol which in turn reduces abdominal fat.” Female Patient, 2001 April; 26: 18-24.

“Estrogen therapy alters the biology of the inner vessels (of the heart). HRT protects through vasodilation, anti-inflammatory and anti-proliferative effects. HRT provides significant coronary artery benefit.” N England J Medicine 2000; 343(8): 572-574.

“Estrogen protects against neuron-degeneration, changes in mood, cognition and behavior.” Clinical Genetics 1998 May; 6(5): 15-19.